Testicular Descent.
نویسندگان
چکیده
1Department of Urology, University General Hospital of Heraklion, University of Crete Medical School, Heraklion, Crete, Greece; 2First Pediatric Surgery Clinic, Aghia Sophia Children’s Hospital, Athens, Greece; 3Department of Urology, Tottori University School of Medicine, Yonago, Japan; 4Laboratory of Molecular Urology and Genetics of Human Reproduction, Department of Urology, Ioannina University School of Medicine, Ioannina, Greece Review HORMONES 2015, 14(4):515-530
منابع مشابه
Genetics and hormones in testicular descent.
Testicular descent is an essential part of normal male sexual development. Any anomaly that disrupts normal testicular descent will be clinically evident as cryptorchidism. Several factors, such as Hoxa-10, epidermal growth factor (EGF), calcitonin gene-related peptide (CGRP), and hormones, especially androgens and insulin-like factor 3 (INSL-3), have been suggested as being regulators of testi...
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Testicular development is a very interesting aspect of male reproduction and fertility. The primordial germ cells migrate from yolk sac to the genital ridge along the wall of the hindgut and the dorsal mesentery to ultimately settle in the genital ridge that would give rise to testes. Sex-determining region of the Y chromosome (SRY) is the principal driver of testes development. Testes developm...
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BACKGROUND Testicular descent in boys is now routinely screened only once, at 6-8 weeks of age. Early surgery for undescended testes is recommended. AIM To assess the value of screening for testicular descent at 6-8 weeks, 8-9 months, and 39-42 months of age. DESIGN OF STUDY Observational study. SETTING Royal Hospital for Sick Children, Glasgow and the Scottish community-based Child Healt...
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The ontogeny of Müllerian inhibiting substance (MIS) production by the developing testis of an Australian marsupial, the tammar wallaby (Macropus eugenii), was determined during pouch life using an organ-culture bioassay of mouse fetal urogenital ridge. This information was related to the morphological events during testicular migration and descent. MIS biological activity was found in testes (...
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Testicular descent is a unique physiological adaptation found in therian mammals allowing optimal spermatogenesis below core body temperature. Recent studies show that INSL3, produced by Leydig cells, and its receptor LGR8 (RXFP2) are essential for mediating the transabdominal phase of testicular descent during early development. However, the origin and genetic basis for this physiological adap...
متن کاملDevelopment, structure and function of the cranial suspensory ligaments of the mammalian gonads in a cross-species perspective; their possible role in effecting disturbed testicular descent.
The present review aims to present a perspectiveon a relatively unknown part of the mammalian internal genitalia: their cranial suspensory apparatus. This apparatus shows wide divergence of development when examined during the fetal period or during adulthood, in males or females, or in individuals across a variety of species. In rats and other mamalian species the apparatus undergoes a distinc...
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ورودعنوان ژورنال:
- Hormones
دوره 14 4 شماره
صفحات -
تاریخ انتشار 2015